АНАЛИЗ ПРОФИЛЯ ЭКСПРЕССИИ ИНТЕРФЕРОН-ЗАВИСИМЫХ ГЕНОВ ДЛЯ ДИФФЕРЕНЦИАЛЬНОЙ ДИАГНОСТИКИ ЗАБОЛЕВАНИЙ ИММУННОЙ СИСТЕМЫ (ОБЗОР ЛИТЕРАТУРЫ)

Аннотация

Интерфероны типа 1 (ИФН1) являются ключевыми молекулами противовирусной защиты, а также мощными медиаторами воспаления. В 2003 году было впервые установлено, что в клетках крови пациентов с системной красной волчанкой (СКВ) наблюдалась повышенная экспрессия целого ряда генов, индуцированных интерферонами типа 1. Данный феномен получил название интерфероновой сигнатуры (type 1 interferon signature) или интерферонового профиля. В дальнейшем паттерны экспрессии, свидетельствующие о наличии ИФН1-профиля были обнаружены при разнообразных аутоиммунных и аутовоспалительных состояниях, которые либо наследуются в соответствии с законами Менделя, либо относятся к многофакторным заболеваниям. Количественным показателем, позволяющим оценить степень гиперактивации ИФН1-пути, является т.н. интерфероновый индекс (interferon score).
В настоящем обзоре обсуждаются возможные причины изменения экспрессии интерферон-зависимых генов, клинико-лабораторные подходы к анализу интерферонового индекса, а также практическое использование этого индикатора для диагностики различных заболеваний.

Об авторах

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