БЕТА-КОРОНАВИРУСЫ И ЭНДОКРИННАЯ СИСТЕМА ЧЕЛОВЕКА: НОВЫЕ ДАННЫЕ (ОБЗОР ЛИТЕРАТУРЫ)

Аннотация

Новое опасное респираторное заболевание COVID-19 впервые зарегистрировано в Китае в декабре 2019 г., возбудителем которого является SARS-Coronavirus 2 (SARS-CoV-2), принадлежащий к роду бета-коронавирусов. Помимо SARS-CoV-2 род включает SARS-CoV-1 и MERS-CoV. Геном SARS-CoV-2 почти на 80% схож с SARS-CoV-1 и на 50% — с MERS-CoV. Механизмы заражения SARS-CoV-1 и SARS-CoV-2 также схожи и происходят через связывание вируса с белком ангиотензинпревращающего фермента 2 типа (АСЕ2), широко представленным в организме человека с преобладающей экспрессией в эндокринных тканях. В связи с этим, SARS-CoV-1 и SARS-CoV-2 поражают органы эндокринной системы, вызывая их повреждение и гормональные изменения, влияющие на прогноз течения COVID-19. Данный обзор литературы посвящен анализу изменений в органах эндокринной системы при инфицировании SARS-CoV-1 и SARS-CoV-2, а также потенциальному влиянию гормонов на восприимчивость к SARS-CoV-2.

Об авторах

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