ГИПОВИТАМИНОЗ D У ПОЖИЛЫХ: СВЯЗЬ С САРКОПЕНИЕЙ И ДЕМЕНЦИЕЙ (ОБЗОР ЛИТЕРАТУРЫ)

Аннотация

Рост численности в мировой популяции людей пожилого и старческого возраста провоцирует интерес к процессам и механизмам, ведущим к старению и возраст- ассоциированным заболеваниям. Гиповитаминоз D распространен у гериатрических пациентов и предложен рядом авторов в качестве причины таких заболеваний, как деменция и саркопения. Данный обзор литературы посвящен анализу роли витамина D в развитии вышеуказанных заболеваний, их профилактике и лечении.

Об авторах

Список литературы

Ruan Q., Yu Z., Chen M., Bao Z., Li J., He W. Cognitive frailty, a novel target for the prevention of elderly dependency. Ageing Res. Rev. 2015; 20: 1-10

Булгакова С.В., Тренева Е.В., Захарова Н.О., Труханова И.Г., Нестеренко С.А., Лебедева Е.А. Саркопения: многокомпонентная стратегия диагностики и терапии (обзор литературы). Успехи геронтологии. 2019; 32 (3): 405-14.

Романчук Н.П., Пятин В.Ф., Волобуев А.Н., Булгакова С.В., Тренева Е.В., Романов Д.В. Мозг, депрессия, эпигенетика: новые данные. Бюллетень науки и практики. 2020; 6 (5): 163-83.

Cruz-Jentoft A.J., Bahat G., Bauer J., Boirie Y., Bruyère O., Cederholm T. et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019; 48: 16-31.

Mayhew A.J., Amog K., Phillips S., Parise G., McNicholas P.D., de Souza R.J. et al. The prevalence of sarcopenia in community-dwelling older adults, an exploration of differences between studies and within definitions: a systematic review and meta-analyses. Age Ageing. 2019; 48: 48-56.

D’Amelio P., Quacquarelli L. Hypovitaminosis D and aging: is there a role in muscle and brain health? Nutrients. 2020; 12(3): 628.

World Alzheimer Report 2018: The state of the art of dementia research: new frontiers Alzheimer’s disease international. [(accessed on 28 January 2020)]; Available online: https://www.alz.co.uk/news/world-alzheimer-report-2018-state-of-art-of-dementia-research-new-frontiers.

Пигарова Е.А., Рожинская Л.Я., Белая Ж.Е., Дзеранова Л.К., Каронова Т.Л., Ильин А.В. и др. Клинические рекомендации Российской ассоциации эндокринологов по диагностике, лечению и профилактике дефицита витамина D у взрослых. Проблемы эндокринологии. 2016; 62(4): 60-84

Halfon M., Phan O., Teta D. Vitamin D: a review on its effects on muscle strength, the risk of fall, and frailty. Biomed. Res. Int. 2015; 2015: 953241-53.

Tanaka M., Kishimoto K.N., Okuno H., Saito H., Itoi E. Vitamin D receptor gene silencing effects on differentiation of myogenic cell lines. Muscle Nerve. 2014; 49: 700-708.

Santillán G., Katz S., Vazquez G., Boland R.L. TRPC3-like protein and vitamin D receptor mediate 1alpha, 25(OH)2D3-induced SOC influx in muscle cells. Int. J. Biochem. Cell Biol. 2004; 36: 1910-18.

Buitrago C., Vazquez G., De Boland A.R., Boland R.L. Activation of Src kinase in skeletal muscle cells by 1,25-(OH(2))-vitamin D(3) correlates with tyrosine phosphorylation of the vitamin D receptor (VDR) and VDR-Src interaction. J. Cell. Biochem. 2000; 79: 274-81.

Buitrago C., González Pardo V., de Boland A.R. Nongenomic action of 1 alpha, 25(OH)(2)-vitamin D3 activation of muscle cell PLC gamma through the tyrosine kinase c-Src and PtdIns 3-kinase. Eur. J. Biochem. 2002; 269: 2506-15.

Endo I., Inoue D., Mitsui T., Umaki Y., Akaike M., Yoshizawa T. et al. Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology. 2003; 144: 5138-44.

Bhat M., Kalam R., Qadri S.S., Madabushi S., Ismail A. Vitamin D deficiency-induced muscle wasting occurs through the ubiquitin proteasome pathway and is partially corrected by calcium in male rats. Endocrinology. 2013; 154: 4018-29.

Girgis C.M., Clifton-Bligh R.J., Turner N., Lau S.L., Gunton J.E. Effects of vitamin D in skeletal muscle: falls, strength, athletic performance and insulin sensitivity. Clin. Endocrinol. 2014; 80: 169-81.

Lappe J.M., Binkley N. Vitamin D and sarcopenia/falls. J. Clin. Densit. 2015; 18: 478-82.

Verde Z., Giaquinta A., Sainz C.M., Ondina M.D., Araque A.F. Bone Mineral Metabolism Status, Quality of Life, and Muscle Strength in Older People. Nutrients. 2019; 11: 2748-55.

Aspell N., Laird E., Healy M., Lawlor B., O’Sullivan M. Vitamin D Deficiency Is Associated With Impaired Muscle Strength And Physical Performance In Community-Dwelling Older Adults: Findings From The English Longitudinal Study Of Ageing. Clin. Interv. Aging. 2019; 14: 1751-61.

Houston D.K., Cesari M., Ferrucci L. Association between vitamin D status and physical performance: the InCHIANTI study. Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2007; 62(4): 440-6.

Toffanello E.D., Perissinotto E., Sergi G. Vitamin D and physical performance in elderly subjects: the Pro.V.A study. PLoS ONE. 2012; 7(4): e34950-e34955.

Sleeman I., Aspray T., Lawson R., Coleman S., Duncan G., Khoo T.K. et al. The role of vitamin D in disease progression in early Parkinson’s disease. J. Parkinsons Dis. 2017; 7: 669-75.

Tabrizi R., Hallajzadeh J., Mirhosseini N., Lankarani K.B., Maharlouei N., Akbari M. et al. The effects of vitamin D supplementation on muscle function among postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. EXCLI J. 2019; 18: 591-603.

Bischoff-Ferrari H.A., Dawson-Hughes B., Orav E.J., Staehelin H.B., Meyer O.W., Theiler R. et al. Monthly high-dose vitamin D treatment for the prevention of functional decline: a randomized clinical trial. JAMA Intern. Med. 2016; 176: 175-83.

Glendenning P., Zhu K., Inderjeeth C., Howat P., Lewis J.R., Prince R.L. Effects of three-monthly oral 150,000 IU cholecalciferol supplementation on falls, mobility, and muscle strength in older postmenopausal women: a randomized controlled trial. Journal of Bone and Mineral Research. 2012; 27(1): 170-6.

Cesareo R., Attanasio R., Caputo M., Castello R., Chiodini I., Falchetti A. et al. Italian association of clinical endocrinologists (AME) and Italian chapter of the American association of clinical endocrinologists (AACE) position statement: clinical management of vitamin D deficiency in adults. Nutrients. 2018; 10: 546-8.

Saha S., Goswami R., Ramakrishnan L., Vishnubhatla S., Mahtab S., Kar P. et al. Vitamin D and calcium supplementation, skeletal muscle strength and serum testosterone in young healthy adult males: Randomized control trial. Clin. Endocrinol. 2018; 88: 217-26.

Beauchet O., Launay C.P., Galery K., Vilcocq C., Dontot-Payen F., Rousseau B. et al. Effects of vitamin D and calcium fortified yogurts on gait, cognitive performances, and serum 25-hydroxyvitamin D concentrations in older community-dwelling females: results from the gait, memory, dietary and vitamin D (GAME-D2) randomized controlled trial. Nutrients. 2019; 11: 2880-8.

Garcion E., Wion-Barbot N., Montero-Menei C.N., Berger F., Wion D. New clues about vitamin D functions in the nervous system. Trends Endocrinol. Metab. 2002; 13: 100-5.

Grimm M.O.W., Lehmann J., Mett J., Zimmer V.C., Grösgen S., Stahlmann C.P. et al. Impact of vitamin D on amyloid precursor protein processing and amyloid-β peptide degradation in Alzheimer’s disease. Neurodegener. Dis. 2014; 13: 75-81.

Landel V., Millet P., Baranger K., Loriod B., Féron F. Vitamin D interacts with Esr1 and Igf1 to regulate molecular pathways relevant to Alzheimer’s disease. Mol. Neurodegener. 2016; 11: 22-5.

Van Schoor N.M., Comijs H.C., Llewellyn D.J., Lips P. Cross-sectional and longitudinal associations between serum 25-hydroxyvitamin D and cognitive functioning. Int. Psychogeriatr. 2016; 28: 759-68.

Gschwind Y.J., Bischoff-Ferrari H.A., Bridenbaugh S.A., Härdi I., Kressig R.W. Association between serum vitamin D status and functional mobility in memory clinic patients aged 65 years and older. Gerontology. 2014; 60: 123-9.

Annweiler C., Maby E., Meyerber M., Beauchet O. Hypovitaminosis D and executive dysfunction in older adults with memory complaint: a memory clinic-based study. Dement. Geriatr. Cogn. Disord. 2014; 37: 286-93.

Maddock J., Zhou A., Cavadino A., Kuźma E., Bao Y., Smart M.C. et al. Vitamin D and cognitive function: a Mendelian randomisation study. Sci. Rep. 2017; 7: 13230-4.

Dhesi J.K., Jackson S.H.D., Bearne L.M., Moniz C., Hurley M.V., Swift C.G. et al. Vitamin D supplementation improves neuromuscular function in older people who fall. Age Ageing. 2004; 33: 589-95.

Przybelski R., Agrawal S., Krueger D., Engelke J.A., Walbrun F., Binkley N. Rapid correction of low vitamin D status in nursing home residents. Osteoporos Int. 2008; 19: 1621-8.

Dean A.J., Bellgrove M.A., Hall T., Phan W.M.J., Eyles D.W., Kvaskoff D. et al. Effects of vitamin D supplementation on cognitive and emotional functioning in young adults — a randomised controlled trial. PLoS ONE. 2011; 6: e25966-70.

Pettersen J.A. Does high dose vitamin D supplementation enhance cognition? A randomized trial in healthy adults. Exp. Gerontol. 2017; 90: 90-7.

Goodwill A.M., Szoeke C. A systematic review and meta-analysis of the effect of low vitamin D on cognition. J. Am. Geriatr. Soc. 2017; 65: 2161-8.

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