КАНДИДЕМИЯ У ОНКОЛОГИЧЕСКИХ БОЛЬНЫХ: ОСОБЕННОСТИ ТАКСОНОМИЧЕСКОЙ СТРУКТУРЫ

Аннотация

Целью исследования было определение основных видов Candida, выделяемых из крови пациентов онкологического стационара, сравнение таксономической структуры штаммов, полученных при кандидемии у детей и взрослых. Всего за исследуемый период микробиологически (метод гемокультур) доказана кандидемия у 81 больного (повторы исключены), из них 29 (35,8%) — пациенты отделения реанимации и интенсивной терапии (ОРИТ). Общее количество изолятов, включенных в разработку, составило 82 штамма Candida spp. (10 видов). В целом в таксономической структуре кандидемий лидирует С. parapsilosis (60,97%), на втором месте — C. albicans (20,7%), на третьем — C. glabrata и C. lusitaniae — по 3,7% каждый вид, на четвертом — C. krusei, C. guilliermondii и C. tropicalis (по 2,4% каждый вид). C. parapsilosis статистически значимо чаще были выделены из крови по сравнению с C. albicans (61,0% против 20,7%, соответственно, p<0,0001). Кандидемия была выявлена статистически значимо чаще у взрослых по сравнению с детьми (63,0% против 37,0%, соответственно, p<0,002). Причем у взрослых статистически достоверно чаще из крови были выделены С. parapsilosis нежели C. albicans (70,6% против 15,7%, соответственно, p<0,0001). У детей достоверных различий в частоте выделения С. parapsilosis и C. albicans не выявлено: доля С. parapsilosis составила 45,2%, C. albicans - 29,0%. Редкие виды у взрослых были выделены в 7,8% случаев, у детей - в 12,9% случаев, но статистически значимых различий по этому параметру выявлено не было. Доля Candida non-albicans составила в целом за исследуемый период 79,3%, и основным видом в этой группе является C. parapsilosis (76,9%).

Об авторах

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