ЛЕКТИНЫ И ГЛИКАНЫ В РЕГУЛЯЦИИ СИСТЕМЫ КОМПЛЕМЕНТА ЧЕЛОВЕКА (ОБЗОР ЛИТЕРАТУРЫ)
Doi: 10.51620/0869-2084-2023-68-5-285-291 ISSN: 0869-2084 (Print) ISSN: 2412-1320 (Online)
Аннотация
Рассмотрено участие гликанов, растворимых и рецепторных белков в регуляции системы комплемента человека (СКЧ). Отмечена широта связей как в самой сети СКЧ, так и с другими системами защиты организма человека. Акцентирован вклад гликанраспознающих и связывающих белков, кофункционирование лектиновых и других составляющих со сборочной протеолитической активностью в СКЧ. СКЧ функционирует как высокочувствительная к гликанам и гликоконъюгатам система. Представленные данные указывают на перспективы СКЧ в клинической лабораторной диагностике и
лечении системных болезней человека.
Список литературы
1. Lakhtin V.M. Роль белков с лектиновыми свойствами в функционировании системыкомплемента. Tsitokini i vospaleniye. 2002;1 (2): 11. (in Russian)
2. Lakhtin M.V., Lakhtin V.M., Afanasiev S.S., Aleshkin V.A., Mironov A.Yu. Lectins and glycoconjugates in presentation of antigens and protection against pathogens:a review. Klinicheskaya Laboratornaya Diagnostika. 2018; 63(10): 619-25. (in Russian)
3. Lakhtin M.V., Lakhtin M.V., Aleshkin V.A., Afanasiev S.S., Mironov A.Yu. Lectin subpopulations of NK cells in adaptive immunity against tumors coupled to viral infections. Klinicheskaya Laboratornaya Diagnostika. 2019; 64(5): 314-20. (in Russian)
4. Microbiocenoses and human health. Aleshkin V.A., Afanasyev S.S., Karaulov A.V., eds. Moscow: Dinastiya; 2015. ISBN 978-5-98125-099-6. (in Russian)
5. Lakhtin M.V., Lakhtin V.M., Afanasyev S.S. Complement system – communicator of human immunity. Modern European science: materials of the XI International scientific and practical conference, Sheffield, June 30-07 2015. Sheffield: Science and education LTD, 2015: 71-80.
6. Lakhtin M. V. Variants of isotyping the human complement component C4. Diss… Moscow; 2008. (in Russian)
7. Kozlov L.V., Burdelev O.O., Bureeva S.V., Kaplun A.P. Artificial inhibition of the complement system (Review article). Bioorganicheskaya khimiya. 2007; 33 (5): 485-510. (in Russian)
8. Lakhtin V.M., Lakhtin M.V., Aleshkin V.A. Chemiluminescent immunoblotting analysis of complement functional activity: C1-inhibitor of patients with a deficiency of the C4 component isotype. News Science Education. 2020; 6 (2): 8-15.
9. Chakraborti S., Dhalla N.S., eds. Serine Proteases in the Lectin Pathway of the Complement System. In: Proteases in Physiology and Pathology. 2017: 397-420. DOI: 10.1007/978-981-10-2513-6_18.
10. Panagiotou A., Trendelenburg M., Osthoff M. The lectin pathway of complement in myocardial ischemia/reperfusion injury – review of its significance and the potential impact of therapeutic interference by C1 esterase inhibitor. Front. Immunol. 2018; 9: 1151. DOI:10.3389/fimmu.2018.01151.
11. Geller A., Yan J. The role of membrane bound complement regulatory proteins in tumor development and cancer immunotherapy. Front. Immunol. 2019; 10: 1074. DOI:10.3389/fimmu.2019.01074.
12. Lakhtin M.V., Lakhtin V.M., Aleshkin V.A., Afanasiev S.S., Aleshkin A.V. Lectins and ensymes in biology and medicine. Moscow: Dinastiya; 2010. (in Russian)
13. Lakhtin M.V., Lakhtin V.M., Afanas’ev S.S., Alyoshkin V.A. Interrelation between the system of complement, Toll-like receptors, CD antigens and cytokines in normal and pathological condition (review). Byulleten` Vostochno-Sibirskogo nauchnogo tsentra Sibirskogo
otdeleniya RAMN. 2015; 6: 62-6. (in Russian)
14. Vandendriessche S., Cambier S., Proost P., Marques P.E. Complement receptors and their role in leukocyte recruitment and phagocytosis. Front. Cell Dev. Biol. 2021; 9: 624025. DOI: 10.3389/
fcell.2021.624025.
15. Xu S., Wang J., Wang J.-H., Springer T.A.. Distinct recognition of complement iC3b by integrins αXβ2 and αMβ2. Proc. Natl. Acad. Sci. USA. 2017; 114(13): 3403-8. DOI:10.1073/pnas.1620881114.
16. Cummings R.D. «Stuck on Sugars – How carbohydrates regulate cell adhesion, recognition, and signaling». Glycoconj. J. 2019; 36(4): 241-57. DOI:10.1007/s10719-019-09876-0.
17. Lakhtin M.V., Lakhtin V.M., Mironov A.Yu., Aleshkin V.A. The C4A isotype system of the C4 complement component: A marker of deep damage by autoimmune diseases. Akusherstvo i ginekologiya: novosti, mneniye, obuchemiye. 2020; 8,1(27): 95. (in Russian)
18. Lakhtin M.V., Lakhtin V.M., Aleshkin V.A., Mironov A.Yu. Subizotypic biomarkers of progressive lesions of antiphospholipid syndrome in combination with systemic lupus erythematosus among patients with C4 deficiency. Uralskiy nauchniy vestnik. 2019; 12 (5):
15-9. (in Russian)
19. Kadkhodayi-Kholghi N., Bhatt J.S., Gor J., McDermott L.C., Gale D.P., Perkins S.J. The solution structure of the complement deregulator FHR5 reveals a compact dimer and provides new insights into CFHR5 nephropathy. J. Biol. Chem. 2020; 295 (48): 16342-58.
DOI:10.1074/jbc.RA120.015132.
20. Ostrycharz E., Hukowska-Szematowicz B. New insights into the role of the complement system in human viral diseases. Biomolecules. 2022; 12 (2): 226. DOI:10.3390/biom12020226.
21. Ghosh P., Sahoo R., Vaidya A., Chorev M., Halperin J.A. Role of complement and complement regulatory proteins in the complications of diabetes. Endocr. Rev. 2015; 36(3): 272-88. DOI:10.1210/ er.2014-1099.
22. Taylor M.E., Drickamer K. Mammalian sugar-binding receptors: known functions and unexplored roles. FEBS J. 2019; 286 (10): 1800-14. doi:10.1111/febs.14759.
23. Lakhtin V.M., Yamskov I.A. Lectins in the study of receptors. Uspekhi khimii. 1991; 60 (8): 1777-1816. (in Russian)
24. Lakhtin V.M., Lakhtin M.V., Davydkin V.Yu., Melikhova A.V., Davydkin I.Yu., Zhilenkova O.G. Enzybiotics with lectin properties and lectinbiotics with enzyme activities – multifunctional modulators of communications in organism: fundamentals and unlimited potential in food industry, biosensors and medicine. European Journal of Biology and Biotechnology. 2021; 2 (1): 38-46. DOI: 10.24018/ejbio.2021.2.1.150.
25. Li D., Wu M. Pattern recognition receptors in health and diseases. Signal Transduct. Target Ther. 2021; 6: 291. DOI:10.1038/s41392- 021-00687-0.
26. Toledo A.G., Sorrentino J.T., Sandoval D.R., Malmström J., Lewis N.E., Esko J.D. A systems view of the heparan sulfate interactome. J. Histochem. Cytochem. 2021; 69 (2): 105-19. DOI:10.1369/0022155420988661.
27. Lakhtin M.V., Lakhtin V.M., Mironov A.Yu., Aleshkin V.A. Prospects for typing isoelectrophoretic deficiencies of the C4 complement system of patients with immunoblotting images in real time. News Science Education. 2019; 12 (5): 24-41.
28. Lakhtin V.M. Molecular organization of lectins. Molekulyarnaya biologiya. 1994; 28 (2): 245-73. (in Russian)
29. Sinha A., Singh A.K., Kadni T.S., Mullick J., Sahu A. Virus-encoded complement regulators: current status. Viruses. 2021; 13(2): 208. DOI:10.3390/v13020208.
30. Pednekar L., Pandit H., Paudyal B., Kaur A., Al-Mozaini M.A., Kouser L., Ghebrehiwet B., Mitchell D.A., Madan T., Kishore U. Complement protein C1q Interacts with DC-SIGN via its globular domain and thus may interfere with HIV-1 transmission. Front. Immunol. 2016; 7: 600. DOI:10.3389/fimmu.2016.00600.
31. Nabi-Afjadi M., Heydari M., Zalpoor H., Arman I., Sadoughi A., Sahami P., Aghazadeh S. Lectins and lectibodies: Potential promising antiviral agents. Cell Mol. Biol. Lett. 2022; 27 (1): 37.
DOI:10.1186/s11658-022-00338-4.
32. Dammen-Brower K., Epler P., Zhu S., Bernstein Z.J., Stabach P.R., Braddock D.T., Spangler J.B., Yarema K.J. Strategies for glycoengineering therapeutic proteins. Front. Chem. 2022; 10: 863118. DOI:10.3389/fchem.2022.863118.
33. Stefanetti G., Borriello F., Richichi B., Zanoni I., Lay L. Immunobiology of carbohydrates: implications for novel vaccine and adjuvant design against infectious diseases. Front. Cell Infect. Microbiol. 2021; 11: 808005. DOI:10.3389/fcimb.2021.808005.
34. Lakhtin M.V., Lakhtin V.M., Afanasyev S.S., Aleshkin V.A. Functioning of protective systems: mucosal immunity and human complement system. Byulleten` Vostochno-Sibirskogo nauchnogo tsentra Sibirskogo otdeleniya RAMN. 2015; 5: 113-22. (in Russian)
35. Lakhtin M.V., Lakhtin V.M., Mironov A.Yu., Aleshkin V.A., Afanasyev S.S. Human lectin supersystems with probiotic and protective effects. Klinicheskaya Laboratornaya Diagnostika. 2020; 65 (4): 231-8. DOI: 10.18821/0869-2020-65-4-231-238.
36. Lakhtin M.V., Lakhtin V.M., Afanasyev S.S., Korsun V.F. Duty molecular-cellular systems of pectin metabolombiotics of a healthy human body. Prakticheskaya fitoterapiya. 2014; 4: 8-13. (in Russian)
37. Lakhtin M.V,. Alyoshkin V.A., Lakhtin V.M., Afanasyev S.S., Pozhalostina L.V., Pospelova V.V. Probiotic lactobacillus and bifidobacterial lectins against Candida albicans and Staphylococcus aureus clinical strains: new class of pathogen biofilm destructors. Probiotics
and Antimicrobial Proteins. 2010; 2 (3): 186-96. DOI: 10.1007/ s12602-010-9046-3.
38. Lakhtin V.M., Lakhtin M.V., Bayrakova A.L., Davydkin V.Yu. Signaling in the microbiocenotic body under conditions of multifactorial stress. Izvestiya GGTU. 2022;3: 17-9. (in Russian)
39. Lakhtin V., Aleshkin V., Lakhtin M., Afanasiev S. Glycoconjugates (GC) in discrimination of GC-recognition systems of probiotic microorganisms. New potential keys for strains and glycometabolome typing / Proceedings of the 20th Intern.Symp.on Glycoconjugates
(GLYCO XX: Nov.29-Dec.4, San Juan, Puerto-Rico, USA). Glycoconjugate Journal. 2009; 26 (7): 876.
40. Lakhtin M.V., Lakhtin V.M., Melikhova A.V., Davydkin I.Yu., Davydkin V.Yu., Aleshkin V.A. Interactions of proteins and glycoconjugates against infections and pathogens: keys to application. Izvestiya GGTU. 2022; 1: 13-8. (in Russian)
41. Dunne O.M., Gao X., Nan R., Gor J., Adamson P.J., Gordon D.L., Moulin M., Haertlein M., Forsyth V.T., Perkins S.J. A Dimerization Site at SCR-17/18 in Factor H clarifies a new mechanism for complement regulatory control. Front. Immunol. 2020; 11: 601895.
DOI:10.3389/fimmu.2020.601895.
42. Hosszu K.K., Valentino A., Vinayagasundaram U., Vinayagasundaram R., Joyce M.G., Ji Y., Peerschke E.I.B., Ghebrehiwet B. DCSIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells. Blood. 2012; 120 (6): 1228-36. DOI:10.1182/blood-2011-07-369728.
43. Wei B., Gao X., Cadang L., Izadi S., Liu P., Zhang H.-M. et al. Fc galactosylation follows consecutive reaction kinetics and enhances immunoglobulin G hexamerization for complement activation. MAbs. 2021; 13 (1): 1893427. DOI:10.1080/19420862.2021.1893427.
44. Moghimia S.M., Simbergc D., Papinie E., Farhangrazig Z.S. Complement activation by drug carriers and particulate pharmaceuticals: principles, challenges and opportunities. Adv. Drug Deliv. Rev. 2020; 157: 83-95. DOI:10.1016/j.addr.2020.04.012.
45. Nissilä E., Douillard F.P., Ritari J., Paulin L., Järvinen H.M., Rasinkangas P., Haapasalo K., Meri S., Jarva H., de Vos W.M. Genotypic and phenotypic diversity of Lactobacillus rhamnosus
clinical isolates, their comparison with strain GG and their recognition by complement system. PLoS One. 2017; 12 (5): e0176739. DOI:10.1371/journal.pone.0176739.
46. Lakhtin M.V., Lakhtin V.M., Aleshkin V.A. The role of lectins of microorganisms of the indigenous mucosal microflora in the regulation of microbiocenoses of mucous membranes of open body cavities and immunobiological surveillance. Uralskiy nauchniy vestnik.
2020; 4(2): 9-41. (in Russian)
47. Lakhtin M.V., Lakhtin V.M., Aleshkin V.A. The role and prospects of lectins of microorganisms of the indigenous mucosal microflora in the regulation of microbiocenoses of mucous open cavities of the body. Problemy nauchnoy mysli. 2020; 4 (1): 6-23. ISSN 1561-
6916. (in Russian)
48. Medical microbiology, virology and immunology: Textbook for medical university students. Vorobyev A.A., Bykov A.S., Boychenko M.N., eds. 2rd ed. Moscow: Meditsinskoe informatsionnoe
agentstvo; 2015. ISBN 978-5-89481-895-5. (in Russian)
Для цитирования:
Лахтин М.В., Лахтин В.М., Миронов А.Ю., Алёшкин В.А. Лектины и гликаны в регуляции системы
комплемента человека (обзор литературы). Клиническая лабораторная диагностика. 2023; 68 (5): 285-291.
DOI: https://doi.org/10.51620/0869-2084-2023-68-5-285-291
For citation:
Lakhtin M.V., Lakhtin V.M., Mironov A.Yu., Aleshkin V.A. Lectins and glycans in regulation of the human
complement system (review of literature). Klinicheskaya Laboratornaya Diagnostika (Russian Clinical Laboratory Diagnostics). 2023; 68(5): 285-291 (in Russ.) DOI: https: //doi.org/10.51620/0869-2084-2023-68-5-285-291