Аннотация
Псориаз — хроническое иммуноопосредованное системное заболевание. Патогенез псориаза включает сложное взаимодействие генетических, экологических и иммунных факторов. Необходима своевременная диагностика псориаза. Иммунобиологические методы диагностики весьма дорогостоящие. Не разработаны дешевые и экономически доступные иммунные маркеры , которые можно было бы использовать в повседневной клинической практике для оценки степени воспаления и ответа на терапию при псориазе. Для диагностики интенсивности псориатического воспаления представляют интерес соотношение нейтрофилов к лимфоцитам (neutrophil-to-lymphocyte ratio, NLR), соотношение тромбоцитов к лимфоцитам (platelet-to-lymphocyte ratio, PLR), соотношение моноцитов к лимфоцитам (monocyte-to-lymphocyte ratio, MLR) или производное соотношение нейтрофилов к лимфоцитам (derived neutrophil-to-lymphocyte ratio, d-NLR). Это биомаркеры системного воспаления на основе цельных клеток крови, которые коррелируют с тяжестью псориаза. Некоторые авторы изучали комплексные маркеры, такие как системный иммунный индекс (systemic immune index, SII), системный индекс иммунного ответа (systemic immune response index, SIRI) и совокупный индекс системного воспаления (aggregate index of systemic inflammation, AISI). Представляет интерес применение этих биомаркеров для диагностики псориаза, риска прогрессирования и прогнозирования его осложнений.
Annotation
Psoriasis is a chronic immune-mediated systemic disease. The pathogenesis of psoriasis involves a complex interaction of genetic, environmental and immune factors. Timely diagnosis of this disease is essential. However, immunobiological diagnostic methods are very expensive. There are no immune markers yet available that are cheap and affordable enough to be used in routine clinical practice to assess the degree of inflammation and response to therapy in psoriasis. For the diagnosis of the intensity of psoriatic inflammation, the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) or derived neutrophil-to-lymphocyte ratio (d-NLR) are of interest. These are whole blood cell-based biomarkers of systemic inflammation that correlate with the severity of psoriasis. Some authors have studied composite markers such as the systemic immune index (SII), the systemic immune response index (SIRI), and the aggregate index of systemic inflammation (AISI). Of interest is the use of these biomarkers for the diagnosis of psoriasis, the risk of progression, and the prediction of its complications.
Key words: psoriasis; chronic inflammation; systemic immune response index; SIRI, interleukins; cytokines; neutrophil to lymphocyte ratio; NLR; platelet to lymphocyte ratio; PLR
Список литературы
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