Триглицеридно-глюкозный индекс и инсульт (обзор литературы)

Аннотация

Инсульты значительно ухудшают качество жизни и влекут за собой большое экономическое и социальное бремя. Инсулинорезистентность является признанным ключевым фактором риска развития сердечно-сосудистых и цереброваскулярных заболеваний. Триглицеридно-глюкозный индекс является биохимическим маркером инсулинорезистентности и может иметь важное значение в прогнозировании инсультов. Триглицеридно-глюкозный индекс рассчитывается как ln (триглицериды натощак (мг/дл)×глюкоза крови натощак (мг/дл)/2). Триглицеридно-глюкозный индекс является экономически эффективным и легко воспроизводимым показателем оценки инсулинорезистентности. Все большее число исследователей сообщают, что повышенные значения триглицеридно-глюкозного индекса тесно связаны с увеличением неблагоприятных сердечно-сосудистых событий в общей популяции и во многих других когортах пациентов с высоким риском таких заболеваний, как сахарный диабет и артериальная гипертензия. Существует значительная связь между высоким триглицеридно-глюкозным индексом и многими неблагоприятными исходами инсульта, особенно развитием повторного инсульта и риском смерти. Выявление людей, склонных к инсульту, и эффективная первичная профилактика остается важной, но непростой задачей. С этой целью в этом обзоре мы кратко описываем использование триглицеридно-глюкозного индекса в качестве суррогатного маркера для инсулинорезистентности. Мы стремились подчеркнуть прикладную ценность определения величины триглицеридно-глюкозного индекса для различных типов сердечно-сосудистых заболеваний и изучить возможность использования этого индекса в качестве предиктора сердечно-сосудистых событий, чтобы повысить его применимость и предоставить более обширные и точные подтверждающие доказательства.

Annotation

Strokes significantly worsen quality of life and impose a large economic and social burden. Insulin resistance is a recognized key risk factor for cardiovascular and cerebrovascular diseases. The triglyceride-glucose index is a biochemical marker of insulin resistance and may be important in predicting strokes. The triglyceride-glucose index is calculated as ln (fasting triglycerides (mg/dL) × fasting blood glucose (mg/dL)/2). The triglyceride-glucose index is a cost-effective and easily reproducible marker for assessing insulin resistance. An increasing number of studies report that elevated triglyceride-glucose index values are closely associated with an increased incidence of adverse cardiovascular events in the general population and in many other high-risk patient cohorts, such as those with diabetes mellitus and hypertension. There is a significant association between a high triglyceride-glucose index and many adverse stroke outcomes, particularly the development of recurrent stroke and the risk of death. Identifying individuals at risk of stroke and implementing effective primary prevention remains an important but challenging task. In this review, we briefly outline the use of the triglyceride-glucose index as a surrogate marker for insulin resistance. This study sought to underscore the applied importance of the triglyceride-glucose index in the context of diverse cardiovascular diseases and to examine its predictive capacity for cardiovascular events, with the ultimate aim of increasing its utility and furnishing more extensive and rigorous supporting evidence.

Key words: stroke; insulin resistance; triglyceride-glucose index; review

Об авторах

Список литературы

ЛИТЕРАТУРА (пп. 1-4, 6-8, 10-61, 63 см.REFERENCES)
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9. Пизова Н.В., Пизов А.В. Повторный ишемический инсульт и его профилактика. Медицинский совет. 2024; (12):8-14. DOI: 10.21518/ms2024-261.
62. Пономарева М.С., Щепанкевич Л.А., Рерих К.В. Затынко А.В., Антонова К.В., Танашян М.М. Метаболические предикторы течения ишемического инсульта у молодых. Анналы клинической и экспериментальной неврологии. 2025; 19(1):21-9. DOI: 10.17816/ACEN.1274.

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